ICIBM 2019: International Conference on Intelligent Biology and Medicine Colombus, OH, United States, June 9-11, 2019 |
Conference website | http://icibm2019.org |
Abstract registration deadline | March 30, 2019 |
Submission deadline | March 30, 2019 |
ICIBM 2019 is a meeting ground for researchers interested in providing an ideal opportunity to present new findings to enlighten a community, both in exciting new research and feedback. The ICIBM 2019 is a conference that provide opportunities for scholars to serve the broader community through presenting research that challenges, clarifies, and advances learning and technologies that affect cultural, economic, and scientific development, and many other areas, at home and abroad.
Participating in and presenting at academic conferences is worth the effort! Benefits flowing out of one’s involvement at a conference often continue long after the conference has ended. This is the case even if there are difficulties and risks in scouting out and making it to those important conferences. The needed planning and extra research and work it takes make possible the many benefits that can follow from seriously engaging in academic conference. Conferences help teach PhD students as they work towards their degrees how to put their best foot forward as they look towards their future careers.
Conference participation will also give you as a PhD student greater access, going forward in your research, to personal and scholarly resources, important individuals and topics. Listening and paying attention to other presentations will key you in on current trends and discussions. Discussion with peers and established scholars will guide you to new possibilities and discoveries as well as sharpen your perspective on where your own work fits into the field and where to look for more information.
Academic conferences don’t have to be simply stuffy gatherings of professors and researchers, coming together to discuss exotic and arcane topics with merely an “academic” interest and relevance. Even if the topics treated at academic conferences often (but certainly not always!) fall out of the “mainstream” range of interests, conference gatherings are established upon the conviction that research and scholarship is interdependent with and flows out of the broader social, scientific, economic, religious, etc., contexts in which scholarship is pursued.
With all the advantages listed above, I believe that the ICIBM 2019 conference will allow me to broaden my research endeavors so the diseases that plague humanity can finally be diminished, and if not, cured.
Abstract Information:
Title: Analysis of kinesin mutations implicated in neurological disorders
Author list: Vidhyanand Mahase1, Farion Cooper1, Jayla Allums1, Shaolei Teng1,2
Detailed Affiliations
1Department of Biology, Howard University, 2Assistant Professor, Department of Biology, Howard University.
Presenter’s email address [required]: vickmahase0913@gmail.com
Presenter’s phone number: 301-232-2131
Abstract:
The Kinesin family proteins (KIFs) are microtubule-dependent molecular motors that participate in the transport of membrane vesicles/organelles, protein complexes and mRNAs along neurites, thus playing important roles in neuronal function. Many mutations in kinesins are associated with neurological disorders including intellectual disability and hereditary spastic paraplegia. For example, the missense mutations in KIF1A and KIF5A have been found to be implicated in these diseases. In this study, we used structure-based bioinformatics approaches to investigate the damaging mutations in KIFs. The homology modeling was used to construct the structures of Kinesin microtubule binding domain and Kinesin-tubulin complex. The energy calculation methods were applied to determine the effects of missense mutations on protein stability and protein-protein interaction. The results revealed that the mutations associated with intellectual disability and hereditary spastic paraplegia could reduce folding energy and affect binding energy. Many of these mutations are involved in post-translational modifications such as Phosphorylation, Sumoylation, Acetylation and O-Glycosylation. The bioinformatics analyzes provide useful information for understanding the roles of kinesin mutations in the development of neurological disorders.
Keywords (up to six words): KIF1A, KIF5A, bioinformatics, post-translational modifications