ABSTRACT. As humans, things, software, and AI continue to become the entangled fabric of distributed systems, systems engineers and researchers are facing novel challenges. In this talk, we analyze the role of IoT, Edge, and Cloud, as well as AI in the co-evolution of distributed systems for the new decade. We identify challenges and discuss a roadmap that these new distributed systems have to address. We take a closer look at how a cyber-physical fabric will be complemented by AI operationalization to enable seamless end-to-end distributed systems.