Despite the evidence of the Case Management effectiveness in health outcomes, there is no scientific evidence of the implementation and evaluation of the Colombian Health System effectiveness. Objectives: understand nurses’ experiences, facing the implementation of the Case Management Model, for the care of people with pluripathology and their family caregivers.  Method: qualitative descriptive study. Field diaries were made, that collected the significant experiences of the Case Managers Nurses during the intervention. All data were analyzed. Results: 6 Case Managers Nurses participated, with an average age of 31.8 years, 2 or more years of experience in the clinic or community field, all of them has specialization or master’s degree. The emerging categories were: 1. Nurse’s perception about the pluripathological care subject and their social environment. 2. Nursing care experience in Case Management: role, input and difficulties. Conclusions: the perception over people with pluripathology, even it is centered in physiological aspects, in the assessment and care, integrates the spiritual, psychological and social aspects of the subject.