Uncovering the particularities of the dynamical interaction between cancer-related Epithelial-Mesenchymal Transition and the Mammalian Cell Cycle: a feedback-based Boolean networks interconnection approach

Luis Juárez-Ramiro; José Dávila-Velderrain; Alberto Soria-López; Elena R. Álvarez-Buylla; Juan Carlos Martínez-Garcia

doi:10.29007/3kx4

Uncovering the particularities of the dynamical interaction between cancer-related Epithelial-Mesenchymal Transition and the Mammalian Cell Cycle: a feedback-based Boolean networks interconnection approach

10 pages•Published: May 1, 2023

Luis Juárez-Ramiro, José Dávila-Velderrain, Alberto Soria-López, Elena R. Álvarez-Buylla and Juan Carlos Martínez-Garcia

Abstract

Epithelial-to-Mesenchymal Transition (EMT) plays a key role in epithelial-cancer. The state trajectory of its underlying Gene Regulatory Network (GRN) includes three fixed-point attractors characterizing epithelial, senescent, and mesenchymal, cell phenotypes, which implies specific cell-to-cell and cell-to-tissue interactions. The interplay between the GRN driving EMT and the one regulating the Mammalian Cell Cycle (MCC) influences cancer- related cell growing and proliferation. We expose the characteristics of the network arising from the interconnection of the gene regulatory networks associated to EMT and MCC. Our purpose is twofold: first, to elucidate the dynamical properties of cancer-related gene regulatory networks. Subsequently, to propose a computational methodology to address the interconnection of networks related to cancer. Our approach is based on feedback-based interconnection of networks described in discrete Boolean terms.

Keyphrases: complex networks, Discrete Boolean networks, Epithelial cancer, epithelial-to-mesenchymal transition, Feedback-based interactions, gene regulatory networks, mammalian cell cycle, Systems biology of cancer

In: Hisham Al-Mubaid, Tamer Aldwairi and Oliver Eulenstein (editors). Proceedings of International Conference on Bioinformatics and Computational Biology (BICOB-2023), vol 92, pages 1--10

Links:	https://easychair.org/publications/paper/7pTT
	https://doi.org/10.29007/3kx4

BibTeX entry

@inproceedings{BICOB-2023:Uncovering_particularities_of_dynamical,
  author    = {Luis Ju\textbackslash{}'arez-Ramiro and Jos\textbackslash{}'e D\textbackslash{}'avila-Velderrain and Alberto Soria-L\textbackslash{}'opez and Elena R. \textbackslash{}'Alvarez-Buylla and Juan Carlos Mart\textbackslash{}'inez-Garcia},
  title     = {Uncovering the particularities of the dynamical interaction between cancer-related Epithelial-Mesenchymal Transition and the Mammalian Cell Cycle: a feedback-based Boolean networks interconnection approach},
  booktitle = {Proceedings of International Conference on Bioinformatics and Computational Biology (BICOB-2023)},
  editor    = {Hisham Al-Mubaid and Tamer Aldwairi and Oliver Eulenstein},
  series    = {EPiC Series in Computing},
  volume    = {92},
  pages     = {1--10},
  year      = {2023},
  publisher = {EasyChair},
  bibsource = {EasyChair, https://easychair.org},
  issn      = {2398-7340},
  url       = {https://easychair.org/publications/paper/7pTT},
  doi       = {10.29007/3kx4}}

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