Quantifying Clinical Impact: a Comparative Study of Fragility and Relative Risk Indices

EasyChair Preprint no. 12269

Abstract

Clinical decision-making often relies on risk indices to quantify the likelihood of adverse outcomes. Two commonly used indices are fragility index (FI) and relative risk (RR). However, their clinical impact and utility have not been comprehensively compared. In this study, we conducted a comparative analysis of FI and RR to assess their ability to quantify clinical impact across a variety of medical contexts. We analyzed data from multiple clinical trials and observational studies to evaluate the performance of FI and RR in predicting adverse events and guiding clinical decision-making. Our results indicate that while both indices provide valuable information, they capture different aspects of risk and may be more or less informative depending on the specific context. We discuss the strengths and limitations of FI and RR and provide recommendations for their use in clinical practice.

Keyphrases: Clinical Impact, decision making, Fragility index, relative risk, risk assessment

@Booklet{EasyChair:12269,
  author = {Asad Ali},
  title = {Quantifying Clinical Impact: a Comparative Study of Fragility and Relative Risk Indices},
  howpublished = {EasyChair Preprint no. 12269},

  year = {EasyChair, 2024}}